In this YouTube video/podcast, neuroscientist Jason Shephard discusses a study published in the journal Nature that explores the communication between neurons and glioma cells. Neuronal activity is shown to influence glioma progression through the release and secretion of growth hormones, specifically BDNF.
Researchers discovered that glioma cells have TrkB receptors, which could be therapeutic targets, and that neuronal activity leads to an increase in BDNF, contributing to glioma proliferation. Findings suggest that glioma cells may have infrastructure similar to neurons for forming long-term memory, and synaptic interaction between neurons and glioma cells is implicated. The study also revealed that the activity of the environment around the glioma affects its proliferation through synaptic connections. Researchers are currently exploring potential therapeutic options to inhibit glioma proliferation using drugs and are continuing to investigate the roles of BDNF, TrkB, and calcium signals in glioma synapses
Listen to the full podcast at: https://www.youtube.com/watch?v=UpYT-IfYrtY&ab_channel=MicrobeTV