The study presented at the American Physiology Summit investigates the connection between DNA damage, exercise, and heart health in mice. The researchers, led by Jisok Lim, PhD, found that increased physical activity is associated with reduced DNA damage, particularly in endothelial cells that line blood vessels. These cells are exposed to shear stress, which can lead to atherosclerosis.
Telomeres, protective caps on chromosomes, play a role in biological aging and are sensitive to damage by shear stress. Exercise appears to protect telomere function and reduce DNA damage, potentially explaining how it benefits vascular health, even in older age. This study contributes to the understanding of how exercise impacts DNA damage and telomere function, suggesting a potential avenue for personalised interventions in cardiovascular health.
How important do you think understanding the relationship between exercise, DNA damage, and telomere function is for improving cardiovascular health, especially as we age?