In a cohort study published in The Lancet Regional Health – Europe, researchers from Sweden and Finland investigated the association between parental psychiatric disorders and the risk of offspring developing autism spectrum disorder (ASD). They found that offspring had the highest risk of ASD when both parents had psychiatric disorders, with impacted mothers showing a higher risk compared to impacted fathers alone.
The study, leveraging data from Swedish and Finnish nationwide registers, included over 2.5 million children followed up for a mean of 11 years. Results indicated that parental psychiatric disorders, whether in fathers only, mothers only, or both parents, were associated with an increased risk of ASD in offspring compared to parents without diagnosed psychiatric disorders. Comorbid psychiatric disorders in parents further elevated the risk of ASD in offspring. The study underscores the importance of understanding the influence of parental psychiatric health on offspring neurodevelopmental outcomes.