Parental Traits Provide Deeper Insight into Neurodevelopmental Disorders in Children

Researchers discovered that assessing parental traits related to neurodevelopmental and psychiatric disorders yields a more accurate prediction of these conditions in children compared to relying solely on genetic testing. The study, involving an analysis of 97,000 families, indicated an elevated risk of disorders like autism and schizophrenia when both parents exhibited traits such as depression and anxiety. This method surpasses conventional genetic screenings by considering intricate genetic variations passed on by parents that might be overlooked otherwise. The findings emphasize the significance of incorporating both genetic and trait-based inheritance for a comprehensive understanding and potential treatment of neurodevelopmental disorders.

Key Points:

  • The study examined neurodevelopmental and psychiatric traits in over 97,000 families, revealing a higher prevalence of disorders in children when both parents displayed related traits.
  • This approach offers a more nuanced comprehension of disease inheritance, suggesting that assortative mating based on psychiatric and neurodevelopmental traits can impact the severity and occurrence of these conditions in offspring.
  • The research underscores the potential of using parental traits in genetic counseling and developing targeted therapeutic interventions, emphasizing the necessity for a broader approach to predict and manage neurodevelopmental disorders.

Read full article at:

https://www.cell.com/ajhg/fulltext/S0002-9297(23)00393-2

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